Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury.

@article{Widenfalk2003VascularEG,
  title={Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury.},
  author={Johan Widenfalk and Adam Lipson and Marie Jubran and Christoph Hofstetter and Ted Ebendal and Yan-jun Cao and Lars Olson},
  journal={Neuroscience},
  year={2003},
  volume={120 4},
  pages={951-60}
}
Spinal cord injury leads to acute local ischemia, which may contribute to secondary degeneration. Hypoxia stimulates angiogenesis through a cascade of events, involving angiogenesis stimulatory substances, such as vascular endothelial growth factor (VEGF). To test the importance of angiogenesis for functional outcome and wound healing in spinal cord injury VEGF165 (proangiogenic), Ringer's (control) or angiostatin (antiangiogenic) were delivered locally immediately after a contusion injury… CONTINUE READING

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