Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial.

@article{Ropper2009VascularEG,
  title={Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial.},
  author={Allan H. Ropper and Kenneth Craig Gorson and Clifton L. Gooch and David H. Weinberg and Ann Pieczek and James H. Ware and Joshua Kershen and Adam H Rogers and Drasko Simovic and Peter Schratzberger and Rudolf Kirchmair and Douglas W. Losordo},
  journal={Annals of neurology},
  year={2009},
  volume={65 4},
  pages={362-4}
}
OBJECTIVE Randomized, blinded trial of intramuscular gene transfer using plasmid vascular endothelial growth factor (VEGF) to treat diabetic polyneuropathy. METHODS Diabetic patients with polyneuropathy were randomized to receive a VEGF-to-placebo ratio of 3:1. Three sets of injections were given at eight standardized sites adjacent to the sciatic, peroneal, and tibial nerves of one leg. Primary outcomes were change in symptom score at 6 months and a prespecified overall clinical and… CONTINUE READING