Vascular endothelial growth factor gene delivery by magnetic DNA nanospheres ameliorates limb ischemia in rabbits.

@article{Jiang2005VascularEG,
  title={Vascular endothelial growth factor gene delivery by magnetic DNA nanospheres ameliorates limb ischemia in rabbits.},
  author={HongChi Jiang and Tiemin Zhang and Xueying Sun},
  journal={The Journal of surgical research},
  year={2005},
  volume={126 1},
  pages={
          48-54
        }
}
BACKGROUND Critical limb ischemia often leads to disability and limb loss. Vascular endothelial growth factor (VEGF), delivered either as recombinant protein or as gene therapy, has been shown to promote arteriogenesis and angiogenesis in animal models of limb ischemia. However, most of the studies used a nonspecific targeting system. MATERIALS AND METHODS Magnetic DNA nanospheres containing expression plasmids encoding VEGF were synthesized, and their morphology, magnetropism, and stability… CONTINUE READING

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