Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection.

@article{Shahbazi2002VascularEG,
  title={Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection.},
  author={Majid Shahbazi and Anthony A Fryer and Vera Pravica and Iain J. Brogan and Helen M. Ramsay and Ian V. Hutchinson and Paul Neil Harden},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 1},
  pages={
          260-4
        }
}
Acute rejection is a major cause of reduced survival of renal allografts. Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells and is expressed widely by renal tissue and T cells. VEGF influences adhesion and migration of leukocytes across the endothelium. This study investigates whether genetically determined variation in VEGF expression influences the development of renal allograft rejection. VEGF promoter polymorphisms were examined by using sequence-specific primer… CONTINUE READING

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