Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.

@article{Lee2009VascularEG,
  title={Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.},
  author={Hyun Sil Lee and Allen Myers and Jean O. Kim},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={180 11},
  pages={1056-67}
}
RATIONALE The pathogenesis of nasal polyps in chronic rhinosinusitis is poorly understood. OBJECTIVES These studies seek to implicate a functional role for vascular endothelial growth factor (VEGF) in perpetuating primary nasal epithelial cell overgrowth, a key feature of hyperplastic polyps. METHODS Comparison of VEGF and receptor expression was assessed by ELISA of nasal lavage, immunohistochemistry of sinus tissue, flow cytometry of nasal epithelial cells, and ELISA of supernatants. VEGF… CONTINUE READING