Vascular endothelial growth factor as a marker of tumor endothelium.

  title={Vascular endothelial growth factor as a marker of tumor endothelium.},
  author={Rolf A Brekken and Xiangwei Huang and Steven W. King and Philip E. Thorpe},
  journal={Cancer research},
  volume={58 9},
Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that is a primary stimulant of the vascularization of solid tumors. VEGF production is induced by oncogenic gene mutations in the tumor cells and by hypoxic conditions inside the tumor mass. Hypoxia and the locally increased concentration of VEGF lead to an up-regulation of VEGF receptor expression on tumor endothelial cells. Therefore, in the tumor microenvironment, there is an up-regulation of both VEGF and its receptor… CONTINUE READING


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