Vascular endothelial growth factor and spinal cord injury pain.

@article{Nesic2010VascularEG,
  title={Vascular endothelial growth factor and spinal cord injury pain.},
  author={Olivera Nesic and Laura M. Sundberg and Juan Jos{\'e} Dur{\'a}n Herrera and V. U. L. Mokkapati and Julieann C Lee and Ponnada A. Narayana},
  journal={Journal of neurotrauma},
  year={2010},
  volume={27 10},
  pages={
          1793-803
        }
}
Vascular endothelial growth factor (VEGF)-A mRNA was previously identified as one of the significantly upregulated transcripts in spinal cord injured tissue from adult rats that developed allodynia. To characterize the role of VEGF-A in the development of pain in spinal cord injury (SCI), we analyzed mechanical allodynia in SCI rats that were treated with either vehicle, VEGF-A isoform 165 (VEGF(165)), or neutralizing VEGF(165)-specific antibody. We have observed that exogenous administration… CONTINUE READING

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