Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.

@article{Salcedo1999VascularEG,
  title={Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.},
  author={Rosalba Salcedo and Ken Wasserman and Howard A Young and Michael C. Grimm and O. M. Zack Howard and Miriam Anver and Hynda K. Kleinman and William Joseph Murphy and Joost J Oppenheim},
  journal={The American journal of pathology},
  year={1999},
  volume={154 4},
  pages={1125-35}
}
The contribution of chemokines toward angiogenesis is currently a focus of intensive investigation. Certain members of the CXC chemokine family can induce bovine capillary endothelial cell migration in vitro and corneal angiogenesis in vivo, and apparently act via binding to their receptors CXCR1 and CXCR2. We used an RNAse protection assay that permitted the simultaneous detection of mRNA for various CXC chemokine receptors in resting human umbilical vein endothelial cells (HUVECs) and… CONTINUE READING
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