Vascular endothelial growth factor

  title={Vascular endothelial growth factor},
  author={Karl Heinz Plate and Peter C. Warnke},
  journal={Journal of Neuro-Oncology},
Vascular endothelial growth factor (VEGF) is a hypoxia-inducibleangiogenesis and vascular permeability factor which is expressedin high amounts in perinecrotic palisading cells inhuman glioblastomas. In vitro VEGF gene expression isenhanced approximately ten times by hypoxia. Current evidencesuggests, that hypoxia is also the driving forcefor VEGF gene expression in glioblastoma cells invivo and represents the most important trigger fortumor angiogenesis and edema. Our approaches to… CONTINUE READING

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High affinity VEGF binding and developmental expression suggests Flk-1as a major regulator of angiogenesis and vasculogenesis

  • B Millauer, S Wizigmann-Voos, +4 authors A Ullrich
  • Cell 72:
  • 1993
Highly Influential
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