Vascular endothelial growth factor C participates in regulation of maspin in extravillous trophoblast cell migration and invasion.

@article{Shi2019VascularEG,
  title={Vascular endothelial growth factor C participates in regulation of maspin in extravillous trophoblast cell migration and invasion.},
  author={Xinwei Shi and Guoqiang Zheng and Hao Liu and Jing Cao and Wanlu Liu and Yuqi Li and Fu-yuan Qiao and Dongrui Deng and Yuanyuan Wu},
  journal={Reproduction, fertility, and development},
  year={2019}
}
Mammary serine protease inhibitor (maspin; also known as serpin family B member 5 (SERPINB5)) plays a vital role in regulating the biological functions of extravillous trophoblast (EVT) cells, but the mechanism remains unclear. Vascular endothelial growth factor (VEGF) C is a signature angiogenic molecule expressed and secreted by first-trimester trophoblasts, and bioinformatics analyses has revealed upregulation of VEGFC in pre-eclampsia. The aim of this study was to explore whether maspin… 
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Subcellular Expression of Maspin in Colorectal Cancer: Friend or Foe
TLDR
The histological and molecular data reveal that synthesis of maspin-based therapeutics might represent a novel individualized therapeutic strategy for patients with CRC and needs further investigation and validation in many human CRC samples.

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TLDR
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TLDR
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  • Xinwei Shi, Yuanyuan Wu, +7 authors F. Qiao
  • Biology
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • 2012
TLDR
It was concluded that the epigenetic modification in promoter region of maspin contributes to incomplete trophoblast invasion, which offers a novel approach for predicting and treating placental dysfunction.
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TLDR
This study provides the first evidence that endogenous maspin is a potent inhibitor of pericellular uPA, and supports a current hypothesis that maspIn blocks tumor invasion and motility by inhibiting localized perice cellular proteolysis.
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