Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons <ce:italic>in vitro</ce:italic> and <ce:italic>in vivo</ce:italic>

@article{Piltonen2011VascularEG,
  title={Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons <ce:italic>in vitro</ce:italic> and <ce:italic>in vivo</ce:italic>},
  author={M. Piltonen and A. Planken and O. Leskel{\"a} and Timo T My{\"o}h{\"a}nen and Pekka T. M{\"a}nnist{\"o}},
  journal={Neuroscience},
  year={2011},
  volume={192},
  pages={550-563}
}
Neurotrophic factors regulate the development and maintenance of the nervous system and protect and repair dopaminergic neurons in animal models of Parkinson's disease (PD). Vascular endothelial growth factors A (VEGF-A) and B have also neurotrophic effects on various types of neurons, including dopaminergic neurons. We examined the ability of the key lymphangiogenic factor VEGF-C to protect dopaminergic cells in vitro and in vivo. The study was initiated by a finding from microarray profiling… CONTINUE READING

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