Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats.

@article{Serpi2011VascularEG,
  title={Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats.},
  author={Raisa E Serpi and Anna-Maria Tolonen and Jenni Huusko and Jaana Rys{\"a} and Olli Tenhunen and Seppo Yl{\"a}-Herttuala and Heikki Ruskoaho},
  journal={Cardiovascular research},
  year={2011},
  volume={89 1},
  pages={204-13}
}
AIMS heart growth and function are angiogenesis-dependent, but little is known concerning the effects of key regulators of angiogenesis on diastolic heart failure. Here, we tested the hypothesis that local vascular endothelial growth factor-B (VEGF-B) gene therapy prevents left ventricular diastolic dysfunction. METHODS AND RESULTS rats were subjected to pressure overload by infusing angiotensin II (33.3 microg/kg/h) for 2 weeks using osmotic minipumps. Intramyocardial delivery of adenoviral… CONTINUE READING

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