Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway.

Abstract

Vaccinia virus (VV) is an enveloped DNA virus from the poxvirus family and has played a crucial role in the eradication of smallpox. It continues to be used in immunotherapy for the prevention of infectious diseases and treatment of cancer. However, the mechanisms of poxvirus entry, the host factors that affect viral virulence, and the reasons for its… (More)
DOI: 10.1128/JVI.00854-12

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