Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease

  title={Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease},
  author={Akiyoshi Handa and Masafumi Gotoh and Kazutoshi Hamada and Kazuhiro Yanagisawa and Hitoshi Yamazaki and Masato Nakamura and Yoshito Ueyama and Joji Mochida and Hiroaki Fukuda},
  journal={Journal of Orthopaedic Research},

angiogenesis in the diabetic frozen shoulder

It is postulate that VEGF is synthesized and secreted in the synovium of diabetic frozen shoulders and V EGF may have some role in the pathogenesis and neovascularization of frozen shoulders in diabetic patients.

What is the role of systemic conditions and options for manipulation of bone formation and bone resorption in rotator cuff tendon healing and repair?

Systemic conditions such as diabetes mellitus, hypocholesteremia, thyroid disease, and smoking significantly affect the outcomes of rotator cuff repair and have significant implications for the management of these patients.

Chronicity is associated with the glenohumeral synovitis in patients with a rotator cuff tear

The results suggest that GHJsynovitis might be more involved in the pathogenesis for pain and tear progression of rotator cuff disease compared with SAS synovitis.

Analysis of the Cellular and Matrix Composition of Subacromial Bursal Tissue.

Growth factor delivery strategies for rotator cuff repair and regeneration.

The Relationship Between Generalized Joint Hypermobility and Adhesive Capsulitis of the Shoulder

It is suggested that in GJH patients the authors can be more optimistic regarding the concern of the conversion of shoulder pain to AC and if this has already taken place, then these patients may respond more positively to treatment in cases involving GJh.



Vascular endothelial growth factor (VEGF) expression in the subacromial bursa is increased in patients with impingement syndrome

  • K. YanagisawaK. Hamada H. Fukuda
  • Medicine, Biology
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2001

Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases

An increased amount of substance P in the subacromial bursa appears to correlate with the pain caused by rotator cuff disease.

Increased interleukin‐1β production in the synovium of glenohumeral joints with anterior instability

  • M. GotohK. Hamada H. Fukuda
  • Biology, Medicine
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 1999
The increased production of interleukin‐1β in the synovium of the glenohumeral joint in patients with anterior instability is confirmed, suggesting the presence of chronic inflammation at the site.

ADHESIVE CAPSULITIS OF THE SHOULDER: A Study of the Pathological Findings in Periarthritis of the Shoulder

The microscopic sections revealed a nearly consistent pathological picture of reparative inflammatory changes, which consisted of degeneration, vascular repair, cuffing of the blood vessels, and mononuclear cells to a lesser or greater degree.

Shoulder capsulitis in type I and II diabetic patients: association with diabetic complications and related diseases.

Shoulder capsulitis is common in type I and type II diabetic patients and related diseases, and is associated with autonomic neuropathy in types I and II diabetic subjects and with history of myocardial infarction intype I diabetic patients, independently of time related variables.

Rotator interval lesion.

Evidence is presented for the importance of diagnosis and treatment of RI lesions in patients with persistent pain in the shoulder and for a close fit of the supraspinatus and the subscapularis attachments.

Repair of the rotator cuff. End-result study of factors influencing reconstruction.

In fifty patients who had fifty tears of the rotator cuff that had been repaired, correlations of the preoperative findings by history, physical examination, and radiography with the operative findings showed that pain and functional impairment, the primary indications for repair, were significantly relieved.

Shoulder pain with particular reference to the frozen shoulder.

  • F. Simmonds
  • Medicine
    The Journal of bone and joint surgery. British volume
  • 1949
An explanation of the pathogenesis of lesions of the musculo-tendinous cuff is submitted in which the different types of clinico-pathological syndrome are correlated.

VEGF localisation in diabetic retinopathy

Moderate to intense immunostaining was observed in all fibrovascular and fibrocellular membranes examined and supports a circumstantial role for VEGF in the pathogenesis of both the preclinical and proliferative stages of diabetic retinopathy.