Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.

@article{Prager2004VascularEG,
  title={Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.},
  author={Gerald W Prager and Johannes M. Breuss and Stefan Steurer and Judit Mih{\'a}ly and Bernd R. Binder},
  journal={Blood},
  year={2004},
  volume={103 3},
  pages={955-62}
}
Vascular endothelial growth factor (VEGF) is the pivotal angiogenic growth factor activating endothelial cells to migrate, proliferate, and form capillary tubes. For an ordered endothelial cell migration, tissue invasion, and degradation of the extracellular matrix, proteolytic machinery is indispensable. Such machinery, suitable for localized proteolysis, is provided by the prourokinase-urokinase-plasmin system. Prourokinase (pro-uPA), the initial component of this system, is, however… CONTINUE READING