Vascular endothelial growth factor (VEGF) expression in the subacromial bursa is increased in patients with impingement syndrome

  title={Vascular endothelial growth factor (VEGF) expression in the subacromial bursa is increased in patients with impingement syndrome},
  author={Kazuhiro Yanagisawa and Kazutoshi Hamada and Masafumi Gotoh and Tetsuji Tokunaga and Yoshiro Oshika and Masashi Tomisawa and Y H Lee and Akiyoshi Handa and Hiroshi Kijima and Hitoshi Yamazaki and M. Nakamura and Yoshito Ueyama and N. Tamaoki and H. Fukuda},
  journal={Journal of Orthopaedic Research},

Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease

  • A. HandaM. Gotoh H. Fukuda
  • Medicine
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 2003

Effect of Angiogenesis-Related Cytokines on Rotator Cuff Disease: The Search for Sensitive Biomarkers of Early Tendon Degeneration

The pathogenesis of RCD is associated with an imbalance between pro- inflammatory, anti-inflammatory, and vascular ARC, and high blood vessel density in patients with tendon rupture is shown.

The molecular pathophysiology of subacromial bursitis in rotator cuff disease.

Growth factor expression after supraspinatus tear: a quantitative polymerase chain reaction (PCR) study in rats

IL-1β was expressed predominantly in the initial stages after injury; TGF initiated its expression after the initial phase since day three, whereas VEGF remained basically unchanged during the entire process.

Biomolecules Related to Rotator Cuff Pain: A Scoping Review

Investigation of molecules from tissue samples taken from the subacromial bursa, supraspinatus tendon, glenohumeral joint fluid, and synovium as well as from peripheral blood for correlation to pain level finds IL-1b is directly positively correlated to the degree of pain in patients with RC tendinopathy.

Gene Expression Profile Analysis by cDNA Array in the Subacromial Bursa of Patients with Rotator Cuff Disease

This study demonstrated a significant increase in many inflammatory cytokines in the subacromial bursa of patients with rotator cuff disease, which suggests that there is an active inflammatory reaction at the subACromial Bursa in rotators cuff disease.

Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff

Sufficient information was gathered to explain how ectopic expression of BMP might induce tissue transformation into ectopic bone/cartilage and, therefore, promote structural degeneration of the rotator cuff.

The prevalence of neovascularity in patients clinically diagnosed with rotator cuff tendinopathy

It is demonstrated that neovascularity does occur in subjects with a clinical diagnosis of rotator cuff tendinopathy and to a lesser extent in asymptomatic shoulders.

Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents

It is proposed that the resident cells in subacromial bursal tissue produce SDF‐1, which can play a role in the inflammatory reponse of bursesal tissue, and that this chemokine can be regulated by steroid (dexamethasone) and nonsteroidal anti‐inflammatory medications (NSAIDs).



Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis.

In RA, VEGF is synthesized and released by a large number of subsynovial macrophages, fibroblasts surrounding microvessels, vascular smooth muscle cells, and synovial lining cells and may stimulate endothelial proliferation in a paracrine manner via V EGF receptors.

Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis.

A newly described function for V EGF as a potent chemotaxin for endothelial cells as well as a role for VEGF in RA-associated endothelial migration and proliferation are elucidated.

Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta.

Under hypoxia or IL-1 stimulation, conditions common to the inflamed synovium, type B synoviocytes secrete increased levels of VEGF, which is likely to act on nearby endothelia, promoting angiogenesis.

Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer

The results suggest that colon cancer metastasis is critically determined by angiogenesis resulting from the balance between the angioinhibitory factor TSP-2 and angiogenic factor VEGF-189.

Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas.

  • Y. KitadaiK. Haruma E. Tahara
  • Medicine, Biology
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1998
It is suggested that VEGF is associated with tumor progression by stimulating angiogenesis in human esophageal carcinoma by stimulatingAngiogenic profile of human esophileal carcinomas by Northern blot analysis and immunohistochemistry.

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue

Findings indicate that VPF/VEGF may have an important role in the pathogenesis of rheumatoid arthritis, and in situ hybridization studies that were performed on joint tissues from patients with active RA revealed that synovial lining macrophages strongly expressed VPF orVEGF mRNA, and that microvascular endothelial cells of nearby blood vessels strongly expressed mRNA for the VPF /VEGF receptors.

Increased interleukin‐1β production in the synovium of glenohumeral joints with anterior instability

  • M. GotohK. Hamada H. Fukuda
  • Biology, Medicine
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • 1999
The increased production of interleukin‐1β in the synovium of the glenohumeral joint in patients with anterior instability is confirmed, suggesting the presence of chronic inflammation at the site.

Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.

Results suggest that expression of the cell-associated isoform VEGF189 is closely associated with progression of NSCLC.