Vascular endothelial growth factor ‑634G/C polymorphism is associated with increased breast cancer risk and aggressiveness.

@article{Sanguanraksa2013VascularEG,
  title={Vascular endothelial growth factor ‑634G/C polymorphism is associated with increased breast cancer risk and aggressiveness.},
  author={Doonyapat Sa-nguanraksa and Tuenjai Chuangsuwanich and Tawatchai Pongpruttipan and Tanawan Kummalue and Supakorn Rojananin and Adune Ratanawichhitrasin and Poramaporn Prasarttong-Osoth and Suebwong Chuthatisith and Pongthep Pisarnturakit and Waraporn Aeumrithaicharoenchok and Pradit Rushatamukayanunt and Visnu Lohsiriwat and Mongkol Boonsripitayanon and Prida Malasit and Pornchai O-charoenrat},
  journal={Molecular medicine reports},
  year={2013},
  volume={8 4},
  pages={1242-50}
}
Polymorphisms in the promoter and 5' untranslated region of vascular endothelial growth factor (VEGF) have been associated with VEGF levels. To investigate the role of VEGF polymorphisms in breast cancer, the VEGF ‑2578C/A, ‑1498C/T, ‑1154G/A and ‑634G/C polymorphisms were genotyped in 483 breast cancer patients and 524 healthy controls. VEGF mRNA levels in breast cancer tissue were determined using semi‑quantitative RT‑PCR. The genotypes, ‑634G/C and ‑634C/C, were associated with an increased… CONTINUE READING
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