Vascular endothelial growth factor (VEGF) suppresses ovarian granulosa cell apoptosis in vitro.

@article{Kosaka2007VascularEG,
  title={Vascular endothelial growth factor (VEGF) suppresses ovarian granulosa cell apoptosis in vitro.},
  author={Naomichi Kosaka and Natsuko Sudo and Akio Miyamoto and Takashi Shimizu},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={363 3},
  pages={
          733-7
        }
}
Vascular endothelial growth factor (VEGF) inhibits the follicular atresia that resulted from granulosa cell apoptosis in the mammalian ovary. In the present study, we examined the effect of VEGF on granulosa cell apoptosis. Here, we report that VEGF suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) without being associated with the mitochondrial pathway. VEGF did not stimulate or inhibit Bcl-xL and Bax, respectively, in granulosa cells. In addition… CONTINUE READING
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