Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes.

@article{Pufe2004VascularEG,
  title={Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes.},
  author={Thomas Pufe and Viola Harde and Wolf J Petersen and Mary B Goldring and Bernhard N. Tillmann and Rolf Mentlein},
  journal={The Journal of pathology},
  year={2004},
  volume={202 3},
  pages={367-74}
}
VEGF (vascular endothelial growth factor), an important angiogenesis factor, appears also to be involved in inflammatory processes. Recent studies have shown that VEGF and its receptors (VEGFR) are expressed on osteoarthritic, but not on normal adult, chondrocytes. To elucidate possible functions of VEGF in osteoarthritic cartilage, the effects of VEGF were studied on immortalized human chondrocytes. Activated matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, tissue inhibitor of… CONTINUE READING
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