Vascular endothelial growth factor (VEGF) polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analyses.

@article{Nagy2008VascularEG,
  title={Vascular endothelial growth factor (VEGF) polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analyses.},
  author={B{\'a}lint Nagy and Hakan Savli and Attila Molvarec and Tibor V{\'a}rkonyi and Barbara Rig{\'o} and Petronella Hupuczi and J{\'a}nos Rig{\'o}},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2008},
  volume={389 1-2},
  pages={126-31}
}
BACKGROUND The vascular endothelial growth factor (VEGF) has a critical role in vasculogenesis and vascular permeability in several diseases including preeclampsia. There are at least 30 single nucleotide polymorphic (SNP) places on this gene. VEGF G+405C, C-2578A and C-460T SNPs are known to be related to VEGF production. VEGF polymorphisms were studied in preeclampsia, but not in HELLP syndrome. Therefore, we decided to determine the allele and genotype frequencies of VEGF G+405C, C-460T and… CONTINUE READING

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