Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.

@article{Wheatcroft2003VascularEF,
  title={Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.},
  author={Stephen B. Wheatcroft and Mark T Kearney and Ajay M. Shah and David J Grieve and Ian L Williams and John P Miell and Paul A. Crossey},
  journal={Diabetes},
  year={2003},
  volume={52 8},
  pages={2075-82}
}
IGFs and their binding proteins (IGFBPs) play a significant role in metabolic regulation, and there is growing evidence that they also exert important vascular effects. IGFBP-1 contributes to glucose counterregulation, and observational studies demonstrate an inverse association between circulating IGFBP-1 levels and cardiovascular risk factors. Furthermore, IGFBP-1 levels are lower in subjects with overt macrovascular disease. We therefore hypothesized that IGFBP-1 exerts potentially… CONTINUE READING