Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase.

Abstract

To determine whether impaired endothelium-dependent dilation (EDD) in older adults is associated with changes in the expression of major vasoconstrictor or vasodilator proteins in the vascular endothelium, endothelial cells (EC) were obtained from the brachial artery and peripheral veins of 56 healthy men, aged 18-78 yr. Brachial artery EC endothelin-1 (ET… (More)
DOI: 10.1152/ajpheart.00689.2008

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