Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?

  title={Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?},
  author={Zvonimir S. Katu{\vs}i{\'c}},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={281 3},
  • Z. Katušić
  • Published 1 September 2001
  • Biology
  • American journal of physiology. Heart and circulatory physiology
Tetrahydrobiopterin is one of the most potent naturally occurring reducing agents and an essential cofactor required for enzymatic activity of nitric oxide synthase (NOS). The exact role of tetrahydrobiopterin in the control of NOS catalytic activity is not completely understood. Existing evidence suggests that it can act as allosteric and redox cofactors. Suboptimal concentration of tetrahydrobiopterin reduces formation of nitric oxide and favors "uncoupling" of NOS leading to NOS-mediated… 

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