Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

@article{Zeng2013VascularEC,
  title={Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.},
  author={Lingfang Zeng and Qingzhong Xiao and Mei Chen and Andriana Margariti and Daniel Mart{\'i}n and Aleksandar Ivetic and Heping Xu and Justin Mason and Wen Wang and Gillian Cockerill and Kazutoshi Mori and Julie Yi-shuan Li and Shu Chien and Yanhua Hu and Qingbo Xu},
  journal={Circulation},
  year={2013},
  volume={127 16},
  pages={1712-22}
}
BACKGROUND Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothelial cell growth factor signaling and XBP1 pathway. METHODS AND RESULTS We found that vascular endothelial cell growth factor induced the kinase insert domain receptor… CONTINUE READING