Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis.

@article{Koyama2013VascularEA,
  title={Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis.},
  author={Teruhide Koyama and Laura Ochoa-Callejero and Takayuki Sakurai and Akiko Kamiyoshi and Yuka Ichikawa-Shindo and Nobuyoshi Iinuma and Takuma Arai and Takahiro Yoshizawa and Yasuhiro Iesato and Yang Lei and Ryuichi Uetake and Ayano Okimura and Akihiro Yamauchi and Megumu Tanaka and Kyoko Igarashi and Yuichi Toriyama and Hisaka Kawate and Ralf H Adams and Hayato Kawakami and Naoki Mochizuki and Alfredo Mart{\'i}nez and T. Shindo},
  journal={Circulation},
  year={2013},
  volume={127 7},
  pages={842-53}
}
BACKGROUND Revealing the mechanisms underlying the functional integrity of the vascular system could make available novel therapeutic approaches. We previously showed that knocking out the widely expressed peptide adrenomedullin (AM) or receptor activity-modifying protein 2 (RAMP2), an AM-receptor accessory protein, causes vascular abnormalities and is embryonically lethal. Our aim was to investigate the function of the vascular AM-RAMP2 system directly. METHODS AND RESULTS We generated… CONTINUE READING