Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice.

@article{Gunnett1999VascularEO,
  title={Vascular effects of lipopolysaccharide are enhanced in interleukin-10-deficient mice.},
  author={Carol A Gunnett and Daniel J. Berg and Frank M. Faraci and Giora Feuerstein},
  journal={Stroke},
  year={1999},
  volume={30 10},
  pages={2191-5; discussion 2195-6}
}
BACKGROUND AND PURPOSE The role in blood vessels of interleukin-10 (IL-10), a potent anti-inflammatory cytokine, is not known. Using mice with targeted deletion of the gene for IL-10 (IL-10(-/-)), we examined the hypothesis that IL-10 is a major modulator of the vascular effects of lipopolysaccharide (LPS). Methods-We examined in vitro responses of carotid arteries obtained from wild-type (129/SvEv or C57BL/6; IL-10(+/+)) and IL-10-deficient mice 6 hours after injection of a relatively low dose… CONTINUE READING
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Infections as risk factors for infarction and altherosclerosis

  • W. Valtonen
  • Ann Med.1991;23:539–543
  • 1999

Nitric oxide: vascular and parenchymal roles

  • T Dalkara, MA Moskowitz
  • 1998

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