Vascular effects of leukotriene D4 in human skin.

  title={Vascular effects of leukotriene D4 in human skin.},
  author={Hans Bisgaard},
  journal={The Journal of investigative dermatology},
  volume={88 2},
  • Hans Bisgaard
  • Published 1987 in The Journal of investigative dermatology
Leukotriene D4 (LTD4) increased the blood flow rate in human skin, equipotent to histamine in the dose range of 3.1-200 pmol. The vasodilatation lasted for up to 60 min, and no late reactions occurred. Indomethacin did not affect the LTD4-induced blood flow rate. H1 and H2 antagonists reduced the increase in blood flow rate, but did not abolish the response to LTD4. Local nerve block inhibited the axon reflex-mediated flare component of the LTD4-induced blood flow rate, leaving a local red… CONTINUE READING