Vascular effects of aromatase inhibitors: data from clinical trials.

  title={Vascular effects of aromatase inhibitors: data from clinical trials.},
  author={Anthony Howell and Jack Cuzick},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={95 1-5},
Aromatase inhibitors (AIs) are becoming the endocrine treatment of first choice for postmenopausal women with hormone receptor-positive breast cancer and are under investigation for use in breast cancer prevention. AIs reduce circulating estrogen to barely detectable concentrations. It is possible that such a low concentration will be deleterious to the vascular system since estrogen receptors are known to be in the cell walls of blood vessels and estrogen is thought to be important in… CONTINUE READING


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