Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate.

@article{Symons2006VascularDP,
  title={Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate.},
  author={J. David Symons and John C. Rutledge and Ulf Simonsen and Roshny A Pattathu},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 1},
  pages={H181-91}
}
Earlier we reported that dietary folate depletion causes hyperhomocysteinemia (HHcy) and arterial dysfunction in rats (Symons JD, Mullick AE, Ensunsa JL, Ma AA, and Rutledge JC. Arterioscler Thromb Vasc Biol 22: 772-780, 2002). Both HHcy and low folate (LF) are risk factors for cardiovascular disease. Therefore, the dysfunction we observed could have resulted from HHcy, LF, and/or their combination (HHcy + LF). We tested the hypothesis that HHcy-induced vascular dysfunction is more severe in… CONTINUE READING