Vascular dysfunction in sepsis: effects of the peroxynitrite decomposition catalyst MnTMPyP.

@article{Nin2011VascularDI,
  title={Vascular dysfunction in sepsis: effects of the peroxynitrite decomposition catalyst MnTMPyP.},
  author={N. Nin and Mariam El-Assar and Carolina Olarte S{\'a}nchez and Antonio J Ferruelo and Alberto S{\'a}nchez-Ferrer and Leticia Mart{\'i}nez-Caro and Yeny Rojas and Marta Sevilha de Paula and Javier Alexander Hurtado and Andr{\'e}s Esteban and J. A. Lorente},
  journal={Shock},
  year={2011},
  volume={36 2},
  pages={156-61}
}
The mechanisms contributing to sepsis vascular dysfunction are not well known. We tested the hypothesis that peroxynitrite scavenging ameliorates sepsis-induced macrovascular and microvascular dysfunction. Male Sprague-Dawley rats were killed 48 h after cecal ligation (n = 15) and puncture or sham procedure (n = 15). Their aortas and mesenteric vessels were mounted in organ baths for isometric tension recording. We studied contraction in resting vessels (norepinephrine 1 nM-10 μM and 10 nM-10… CONTINUE READING