Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease.

@article{Nowak2017VascularDI,
  title={Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease.},
  author={Kristen L Nowak and Heather Farmer and Melissa A. Cadnapaphornchai and Berenice Y. Gitomer and Michel B. Chonchol},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2017},
  volume={32 2},
  pages={342-347}
}
Background Adults with autosomal dominant polycystic kidney disease (ADPKD) exhibit vascular dysfunction, as evidenced by impaired endothelium-dependent dilation (EDD) and stiffening of the large elastic arteries. However, it is unknown whether vascular dysfunction begins earlier in the course of ADPKD. The aim of the study was to assess EDD and arterial stiffness in children and young adults with ADPKD. Methods Fifteen children and young adults 6–22 years of age with ADPKD and normal renal… CONTINUE READING
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