Vascular disease in scleroderma. Endothelial T lymphocyte-fibroblast interactions.

@article{Kahaleh1990VascularDI,
  title={Vascular disease in scleroderma. Endothelial T lymphocyte-fibroblast interactions.},
  author={M. Bashar Kahaleh},
  journal={Rheumatic diseases clinics of North America},
  year={1990},
  volume={16 1},
  pages={53-73}
}
The accumulated body of evidence suggests a role for a cell-mediated immune mechanism in the pathogenesis of scleroderma vascular disease. The most likely target for immune injury is either the endothelial cell itself or components of its basal lamina, which include type IV collagen and laminin. Whatever the specific target, the net effect is persistently… CONTINUE READING