Vascular development, pulse pressure, and the mechanisms of hypertension.

@article{Safar2005VascularDP,
  title={Vascular development, pulse pressure, and the mechanisms of hypertension.},
  author={Michel E. Safar and Harry A. J. Struijker Boudier},
  journal={Hypertension},
  year={2005},
  volume={46 1},
  pages={205-9}
}
For a given cardiac function, the cyclic blood pressure (BP) curve results from 2 different phenotypes: the mean arterial pressure (MAP), a steady component reflecting the resistance of the microvascular network, and pulse pressure (PP), another component corresponding to large artery stiffness and wave reflections. Around birth, cardiovascular (CV) survival is critically influenced by the coupling between the heart and thoracic aorta, and hence, the adequacy of the Windkessel function, the… CONTINUE READING

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