Vascular deterioration in cirrhosis: the big picture.

  title={Vascular deterioration in cirrhosis: the big picture.},
  author={J Bosch},
  journal={Journal of clinical gastroenterology},
  volume={41 Suppl 3},
  • J Bosch
  • Published 2007 in Journal of clinical gastroenterology
Cirrhosis is characterized by marked abnormalities in the hepatic circulation. Functionally, there is an increased vascular tone and impaired flow-mediated vasorelaxation, whereas anatomically there is sinusoidal remodeling and capillarization, angiogenesis, venous thrombosis, and vascular distortion, all contributing to increase hepatic vascular resistance and portal hypertension. However, vascular changes are not limited to the liver, but are also present in the splanchnic organs, heart… CONTINUE READING


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