Vascular dementia: perfusional and metabolic disturbances and effects of therapy.

@article{Mielke1996VascularDP,
  title={Vascular dementia: perfusional and metabolic disturbances and effects of therapy.},
  author={R. Mielke and J. Kessler and B. Szelies and K. Herholz and K. Wienhard and W. Heiss},
  journal={Journal of neural transmission. Supplementum},
  year={1996},
  volume={47},
  pages={
          183-91
        }
}
Positron emission tomography (PET) has elucidated basic pathophysiological mechanism that produce the cognitive decline in vascular dementia (VD). The typical pattern of glucose metabolism seen in VD with scattered areas of focal cortical and subcortical hypometabolism differs from that in AD with marked hypometabolism affecting the association areas. The total volume of metabolically inactive tissue is significantly related to severity of dementia. Rather than the quantity of tissue… Expand
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