Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

@inproceedings{Crist2018VascularDO,
  title={Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia},
  author={Angela M Crist and Amanda R Lee and Nehal R. Patel and Dawn E Westhoff and Stryder M Meadows},
  booktitle={Angiogenesis},
  year={2018}
}
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder that leads to abnormal connections between arteries and veins termed arteriovenous malformations (AVM). Mutations in TGFβ pathway members ALK1, ENG and SMAD4 lead to HHT. However, a Smad4 mouse model of HHT does not currently exist. We aimed to create and characterize a Smad4 endothelial cell (EC)-specific, inducible knockout mouse (Smad4f/f;Cdh5-CreERT2) that could be used to study AVM development in HHT. We… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES

Essential role of endothelial Smad4 in vascular remodeling and integrity.

  • Molecular and cellular biology
  • 2007
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL