Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis

@article{Hong2006VascularDA,
  title={Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis},
  author={Seung-Beom Hong and Mutsuo Furihata and Masaya Baba and Berton Zbar and Laura S. Schmidt},
  journal={Laboratory Investigation},
  year={2006},
  volume={86},
  pages={664-675}
}
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene leads to the development of central nervous system hemangioblastomas, pheochromocytomas and renal cell carcinomas. The biological role of the VHL gene during development is poorly understood because of early lethality of VHL-null embryos. To overcome early embryo lethality observed in the conventional knockout mouse, we introduced a tamoxifen-inducible Cre (CreERTM) transgene for the stage specific inactivation of the VHL gene… CONTINUE READING