Vascular damage in acute experimental leptospirosis of the guinea-pig.

  title={Vascular damage in acute experimental leptospirosis of the guinea-pig.},
  author={T De Brito and Gy{\"o}rgy Mikl{\'o}s B{\"o}hm and Paulo Hideki Yasuda},
  journal={The Journal of pathology},
  volume={128 4},
The pathogenesis of the haemorrhagic diathesis in experimental leptospirosis of the guinea-pig was investigated in the lung, diaphragm and kidney. The vascular damage was found to be focal and mainly capillary. Swollen endothelium with dilated endoplasmic reticulum, enlarged mitochondriae and open junctions seemed to be the initial lesions and endothelial necrosis the final picture in all tissues. The lung capillaries showed endothelial and epithelial blebs and desquamation with many myelin… CONTINUE READING