Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.

@article{Singh2007VascularCP,
  title={Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.},
  author={Harpreet Singh and Jennifer E. Cheng and Huan Deng and Rowena Kemp and Tsuneo Ishizuka and Alberto Nasjletti and Michal Laniado Schwartzman},
  journal={Hypertension},
  year={2007},
  volume={50 1},
  pages={123-9}
}
Epidemiological evidence suggests a role for sex-dependent mechanisms in the pathophysiology of hypertension. It has been shown that 5alpha-dihydrotestosterone (DHT) administration (56 mg/kg of body weight per day IP for 14 days) increases blood pressure, cytochrome P450 4A expression, and 20-hydroxyeicosatetraenoic acid synthesis in rats. We examined whether increased vascular 20-hydroxyeicosatetraenoic acid synthesis underlies endothelial dysfunction and hypertension in DHT-treated male… CONTINUE READING
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