Vascular contraction and preeclampsia: downregulation of the Angiotensin receptor 1 by hemopexin in vitro.


During normal pregnancy, in contrast to preeclampsia, plasma hemopexin activity is increased together with a decreased vascular angiotensin II receptor (AT(1)) expression. We now tested the hypothesis that hemopexin can downregulate the AT(1) receptor in vitro. Analysis of human monocytes or endothelial cells by flow cytometry showed decreased membrane… (More)
DOI: 10.1161/HYPERTENSIONAHA.108.127951

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