Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

Abstract

Cytochrome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Although CYP4A-derived 20-HETE is known to have prohypertensive and proangiogenic properties, the effects of CYP4F-derived metabolites are not well characterized. To investigate the role of CYP4F2 in vascular disease, we generated mice with… (More)
DOI: 10.1096/fj.13-241927

Topics

  • Presentations referencing similar topics