Vascular changes in tumors resistant to a vascular disrupting nanoparticle treatment.


Anti-angiogenic and vascular disrupting therapies rely on the dependence of tumors on new blood vessels to sustain tumor growth. We previously reported a potent vascular disrupting agent, a theranostic nanosystem consisting of a tumor vasculature-homing peptide (CGKRK) fused to a pro-apoptotic peptide [D(KLAKLAK)2] coated on iron oxide nanoparticles. This… (More)
DOI: 10.1016/j.jconrel.2017.10.006


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