Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma.

@article{LaViolette2013VascularCM,
  title={Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma.},
  author={Peter S LaViolette and Alex Cohen and M A Prah and S D Rand and J Connelly and Mark G. Malkin and W M Mueller and Kathleen M. Schmainda},
  journal={Neuro-oncology},
  year={2013},
  volume={15 4},
  pages={442-50}
}
BACKGROUND Standard pre- and postcontrast (T1 + C) anatomical MR imaging is proving to be insufficient for accurately monitoring bevacizumab treatment response in recurrent glioblastoma (GBM). We present a novel imaging biomarker that detects abnormal tumor vasculature exhibiting both arterial and venous perfusion characteristics. We hypothesized that a decrease in the extent of this abnormal vasculature after bevacizumab treatment would predict treatment efficacy and overall survival… CONTINUE READING

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