Vascular cell adhesion molecule-1 is induced on endothelium during acute rejection in human cardiac allografts.

@article{Carlos1992VascularCA,
  title={Vascular cell adhesion molecule-1 is induced on endothelium during acute rejection in human cardiac allografts.},
  author={Timothy M. Carlos and David Gordon and Daniel P. Fishbein and V E Himes and A Coday and R. Ross and Margaret D. Allen},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={1992},
  volume={11 6},
  pages={1103-8; discussion 1109}
}
An infiltration of mononuclear leukocytes into the myocardium of a cardiac allograft is diagnostic of transplant rejection. The presence of these leukocytes implies their adhesion to, and subsequent migration through, the vascular endothelium. Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are endothelial proteins that have been shown to be involved in the binding of mononuclear leukocytes to the endothelium in vitro. We investigated the induction of these proteins in a… CONTINUE READING