Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells.

@article{Simmons1992VascularCA,
  title={Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells.},
  author={Paul J. Simmons and Boris Masinovsky and Bryan Michael Longenecker and Ronald J. Berenson and Beverly J Torok-Storb and W. Michael Gallatin},
  journal={Blood},
  year={1992},
  volume={80 2},
  pages={388-95}
}
Human bone marrow-derived CD34+ cells were analyzed for the expression of the beta 1-family of integrin adhesion molecules. Integrin alpha 4 beta 1 was consistently expressed by greater than 90% of CD34+ cells, including essentially all assayable granulocyte-macrophage colony-forming cells (CFU-GM) and erythroid bursts (BFU-E) as shown by fluorescence-activated cell sorting studies. Adhesion of highly enriched CD34+ cells to cultured allogeneic marrow stromal cells was largely inhibited both by… CONTINUE READING

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