Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

@article{Moriarty2012VascularBO,
  title={Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.},
  author={Tara J Moriarty and Meiqing Shi and Yi-Pin Lin and Rhodaba Ebady and Hong Jian Zhou and Tanya Odisho and Pierre-Olivier Hardy and Aydan Salman-Dilgimen and Jing Wu and Eric H. Weening and Jon T Skare and Paul Kubes and John M Leong and George Chaconas},
  journal={Molecular microbiology},
  year={2012},
  volume={86 5},
  pages={1116-31}
}
Systemic dissemination of microbial pathogens permits microbes to spread from the initial site of infection to secondary target tissues and is responsible for most mortality due to bacterial infections. Dissemination is a critical stage of disease progression by the Lyme spirochaete, Borrelia burgdorferi. However, many mechanistic features of the process are not yet understood. A key step is adhesion of circulating microbes to vascular surfaces in the face of the shear forces present in flowing… CONTINUE READING
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