Cerebral Hypoperfusion: A New Pathophysiologic Concept in Multiple Sclerosis?
- Biology, MedicineJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Evidence is evolving that cerebral hypoperfusion in MS is associated with chronic hypoxia, focal lesion formation, diffuse axonal degeneration, cognitive dysfunction, and fatigue, and Restoring CBF may emerge as a new therapeutic target in MS.
Cerebrovascular Reactivity in Multiple Sclerosis
- Psychology, Medicine
The results of the studies assessing vasoneuronal coupling in MS patients have showed hyperactivity at the occipital region to visual stimulation during attack, but not attack free period of the disease suggesting that demyelinization and axonal degeneration leads the surviving neurons hyperactive.
Age‐related small vessel disease: a potential contributor to neurodegeneration in multiple sclerosis
- Biology, PsychologyBrain pathology
Several lines of evidence suggest that an interaction between MS and SVD may influence MS‐related neurodegeneration, and therapeutic agents targeting the microvasculature and the neurovascular unit may impact both SVD and MS and may benefit patients with dual pathology.
The multiple sclerosis mystery: is there a vascular component?
- MedicineThe Lancet Neurology
The Role of Cerebral Hypoperfusion in Multiple Sclerosis (ROCHIMS) Trial in Multiple Sclerosis: Insights From Negative Results
- Medicine, PsychologyFrontiers in Neurology
This study showed that CBF in RRMS patients is not always decreased and that bosentan has no effect when CBF values are within the normal range, and hypothesize that in patients there was no significant astrocytic production of ET-1 because they had a mild disease course, with minimal local inflammatory activity.
Role of astrocytes in pathogenesis of multiple sclerosis and their participation in regulation of cerebral circulation.
- Biology, MedicineNeuro endocrinology letters
It appears that complications of cardiovascular disease development precede progressive loss of axons, which mechanisms are complex and should be linked to a loss of β2 adrenergic receptors on astrocytes of demyelinating lesions.
Vascular pathology of multiple sclerosis
- Medicine, BiologyNeurological research
The purpose of this issue of Neurological Research is to synthesize current concepts and most recent findings concerning the evaluation, pathogenesis, and clinical relevance of the vascular pathology of MS.
The Evidence for Hypoperfusion as a Factor in Multiple Sclerosis Lesion Development
- Medicine, BiologyMultiple sclerosis international
It is important that clinical trials addressing vascular issues in MS should examine how the vascular intervention affects white matter perfusion and determine whether the extent of perfusion recovery and maintenance of this recovery is related to functional recovery and Maintenance of functional recovery.
Cerebral hemodynamics in patients with multiple sclerosis.
- Medicine, PsychologyMultiple sclerosis and related disorders
Multiple sclerosis is a systemic venous vasculopathy: A single unifying mechanism.
- Medicine, BiologyMedical hypotheses
SHOWING 1-10 OF 112 REFERENCES
Anomalous Venous Blood Flow and Iron Deposition in Multiple Sclerosis
- Medicine, PsychologyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
The hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage is supported and several recently published studies support the hypothesis that MS progresses along the venous vasculature.
Chronic cerebrospinal venous insufficiency and multiple sclerosis
- MedicineAnnals of neurology
The recent investigations that led to the description of CCSVI are discussed as well as the conceptual and technical shortcomings that challenge the potential relationship of this phenomenon to MS.
Multiple sclerosis appears To be associated with cerebral venous abnormalities
- MedicineAnnals of neurology
The results of the study clearly show that when upright, the average flow through the internal jugular veins of the MS patients was over twice that in the control group, and analysis of the data reveals that the blood flow rate was 2.5 times greater than that of the healthy controls, despite the fact that the cross-sectional area of the IJVs was no greater.
Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
- Medicine, PsychologyBMC medicine
This pilot study is the first to report a significant relationship between the severity of CCSVI and hypoperfusion in the brain parenchyma, and this findings should be confirmed in a larger cohort of MS patients to ensure that they generalize to the MS population as a whole.
White matter hemodynamic abnormalities precede sub-cortical gray matter changes in multiple sclerosis
- Medicine, BiologyJournal of the Neurological Sciences
Increased plasma homocysteine levels in multiple sclerosis
- MedicineMultiple sclerosis
This study aimed to investigate the plasma Hcy levels in a sample of Turkish MS patients and found that there was no correlation between Hcy and vitamin B12 and folate levels, and Hcy was significantly higher in both male and female MS patients when compared to the control groups.
Plasma homocysteine levels in multiple sclerosis
- Medicine, BiologyJournal of Neurology, Neurosurgery & Psychiatry
Elevated plasma homocysteine occurs in both benign and progressive disease courses of MS, and seems unrelated to immune activation, oxidative stress, or a deficiency in vitamin B6, vitamin B12, or folate.
The Immunopathology of Multiple Sclerosis: An Overview
- Psychology, BiologyBrain pathology
Recent evidence is described that the spectrum of MS pathology is much broader, including demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal‐appearing white matter.
["Chronic cerebrospinal venous insufficiency" and multiple sclerosis: critical analysis and first observation in an unselected cohort of MS patients].
- Medicine, PsychologyDer Nervenarzt
The authors conclude that the "chronic cerebrospinal venous insufficiency (CCSVI)" cannot represent the exclusive pathogenetic factor in the pathogenesis of MS, and cannot justify invasive "therapeutic" approaches if they are performed outside of clinical trials.
Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study.
- Medicine, BiologyInternational angiology : a journal of the International Union of Angiology
It is suggested that CCSVI may be an important mechanism related to iron deposition in the brain parenchyma of MS patients and iron deposition, as measured by SWI, is a modest-to-strong predictor of disability progression, lesion volume accumulation and atrophy development in patients with MS.