Vascular and renal function of cGMP signalling

  title={Vascular and renal function of cGMP signalling},
  author={Jens Schlossmann and Elisabeth Schinner and Matthias Desch and Bernhard Hieke and Petra Rothammer and Katharina Salb and Andrea Schramm},
Results For the functional analysis of cGMP signalling, transgenic murine mutants were used. cGKI signalling pathways include interaction of the cGKIb-isozyme with the inositol 1,4,5-trisphosphate receptor I (IP3RI) associated protein cGMP kinase substrate (IRAG). NO/cGMP and ANP/cGMP-dependent relaxation of aortic smooth muscle was strongly affected in… CONTINUE READING