Vascular and metabolic effects of ezetimibe combined with simvastatin in patients with hypercholesterolemia.

@article{Koh2015VascularAM,
  title={Vascular and metabolic effects of ezetimibe combined with simvastatin in patients with hypercholesterolemia.},
  author={Kwang Kon Koh and Pyung Chun Oh and Ichiro Sakuma and Eun Young Kim and Yonghee Lee and Toshio Hayashi and Seung Hwan Han and Yae Min Park and Eak Kyun Shin},
  journal={International journal of cardiology},
  year={2015},
  volume={199},
  pages={126-31}
}
BACKGROUND Ezetimibe demonstrates decreasing visceral fat and improving insulin sensitivity (IS) in animals and humans. We first reported that simvastatin dose-dependently worsens insulin sensitivity. Whether ezetimibe may compensate untoward effects of simvastatin, depending on dosages of simvastatin has not been investigated in patients with hypercholesterolemia, compared with simvastatin alone. METHODS This was a randomized, single-blind, placebo-controlled, parallel study. Fifty-one in… CONTINUE READING