Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress.

@article{Knight2001VascularAH,
  title={Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress.},
  author={Tamara Raphael Knight and Armin Kurtz and Mary Lynn Bajt and Jack A. Hinson and Hartmut Jaeschke},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={62 2},
  pages={212-20}
}
Peroxynitrite may be involved in acetaminophen-induced liver damage. However, it is unclear if peroxynitrite is generated in hepatocytes or in the vasculature. To address this question, we treated C3Heb/FeJ mice with 300 mg/kg acetaminophen and assessed nitrotyrosine protein adducts as indicator for peroxynitrite formation. Vascular nitrotyrosine staining was evident before liver injury between 0.5 and 2 h after acetaminophen treatment. However, liver injury developed parallel to hepatocellular… CONTINUE READING
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